N 358 – N 358 Side Effects, Indication, Usage

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N 358 is a white capsuled-shaped pill that has an imprint of n 358 on it and it has been identified as acetaminophen and hydrocodone bitartrate 325mg / 10mg. This medication is being manufactured and supplied by Novel Laboratories, Inc.

N 358

N 358 contains acetaminophen and hydrocodone bitartrate which are both pain-relieving medications. Acetaminophen is a non-opioid analgesic and also a fever-inducing medication while hydrocodone bitartrate is an opioid analgesic.

N 358 Indications

N 358 is used to treat moderate to severe pain. Hydrocodone, according to researchers, relieves pain by altering how the brain and nervous system respond to unpleasant stimuli.


The dosage of this medication should be changed under the supervision of your prescribing practitioner, but not to exceed the maximum daily dosage allowed. Tolerance to this medication can develop with chronic usage, and increased dosage might lead to more negative effects.

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N 358 Side Effects

The following are some of the most common negative effects related to n 358

  1. Lightheadedness
  2. Dizziness
  3. Sedation
  4. Nausea
  5. Vomiting


People who have previously had an allergic reaction to N 358 should avoid drugs containing these active components.

In the elderly and debilitated, as well as in individuals with significant liver or kidney impairment, hypothyroidism, Addison’s disease, prostatic hypertrophy, or urethral stricture, hydrocodone/acetaminophen should be used with caution.

It’s important to remember that the medicine can cause respiratory depression and that it suppresses the cough mechanism. When taking this medication, patients should not drive or operate machinery. The medication has the potential to become addictive. Speak with your healthcare physician if you find yourself needing additional drugs to attain the same therapeutic benefit.

Pregnant Women’s Special Instructions

Pregnant women should use hydrocodone/acetaminophen with caution. Its usage during pregnancy could cause physical dependence or respiratory issues in the baby. Because hydrocodone/acetaminophen is secreted in breast milk, it should not be used by breastfeeding mothers. 3

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Interactions Between Drugs

Antipsychotics, anti-anxiety drugs, and other central nervous system depressants, such as alcohol and sedatives, may interact with narcotic analgesics and antihistamines such as Texa pills, and Alegra. If you take any of these medications, your healthcare practitioner may need to change your hydrocodone/acetaminophen dose. The side effects of N 358 may be increased if it is taken alongside some other opioid analgesics such as t194, t258, m523, and oc80.

Overdose Symptoms

If you overdose on this medication, then you need to call your doctor immediately and seek medical help some of the overdose symptoms of N 358 are;

Respiratory depression, excessive tiredness that develops into a coma, skeletal muscular flaccidity (limpness), cold or clammy skin, bradycardia (slow heartbeat), and hypotension are all signs and symptoms of an overdose (low blood pressure). There can be apnea, circulatory collapse, cardiac arrest, and death from a very severe overdose. Hepatic necrosis, renal tubular necrosis, hypoglycemia coma, and thrombocytopenia are all possible side effects of acetaminophen (low platelets).

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To prevent acetaminophen overdoses, the FDA has limited the amount of acetaminophen in hydrocodone-containing medicines and other prescription combination treatments containing acetaminophen to 325 mg per tablet.

Hydrocodone-containing medications have also been moved from schedule III to schedule II by the FDA, affecting how the drugs are prescribed and purchased.


This medication should be stored at room temperature. It should be kept away from dust and moisture and should be kept away from children’s reach.

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